Green and efficient protocol for synthesis a new series of fused pyrimidine derivatives incorporating thioamide moiety

In the recent decades, heterocyclic compounds six membered ring occupied a great deals of attention due to its wide and varied applications in medical, pharmaceutical, agricultural industrial fields. Herein this work fused pyrimidine as active type mentioning above have been successfully prepared by using supreme green chemistry techniques represented solid phase one-pot muticomponent reaction (Biginille reaction) microwave irradiation via mixing equimolar thioamide (phenyl thiourea)-dimedone substituted Benzaldehyde presence (2% mole) boric acid few drops glacial acetic selective catalyst at power (700 watt) for (1 min) afford 7,7, dimethyl-1-phenyl-4-aryl-3,4,6,7,8–5H-quinazolin-2-thione-5-one (1-7) pure products with high persentage.